Liposomal Vitamin D in the patented LIPOSHELL® technology

Vitamin D belongs to the group of highly hydrophobic vitamins, which do not dissolve in water. Suspending vitamin D in phospholipid bilayer of LIPOSHELL® liposomes allows for accurate dose control.

One sachet of VITA-D-LIP contains liposomal vitamin D in an amount depending on the dose. Vitamin D supplementation supports:
treatment of deficits identified in patients
helps early prevention of deficiency in a healthy population

What distinguishes VITA-D-LIP from vitamin D in its traditional form?

LIPOSHELL® liposomes ensures high quality of Vitamin D
There is no need to use any additional solvents (e.g. oil) in liposomal vitamin D.
Long-term and stable encapsulation of vitamin D.
Vitamin D contained in the double lipid layer of the liposomes forms a stable dispersion in water.
Facilitated penetration of vitamin into organs & tissues – targeted transport
The liposomes enable the controlled release and effective delivery of the nutrient to the target site – inside the cell.
Small liposomes of 120 nm (+/- 20%) in diameter guarantee high bioavailability
The size of the liposomes in the VITA-D-LIP preparation is optimized for optimal absorption.
Transport of vitamin D in an unchanged form (protection against external factors)
The liposomes form a protective barrier, securing the nutrient against harmful effects of free radicals and degradation factors in the gastrointestinal tract.
LIPOSHELL® technology allows easy absorption of vitamin D. Provides 99.5 % vitamin D encapsulation efficiency.
As the structure of LIPOSHELL® liposomes membrane shows high similarity to the structure of living organisms cell membrane, they are completely biodegradable and biologically inert.

The use of Liposomal Vitamin D in Patented LIPOSHELL® TECHNOLOGY:

The LIPOSHELL® liposomes are tiny carriers with average hydrodynamic diameter of 105 – 120 nm (+/- 20%) with 99.5% vitamin D encapsulation efficiency and bare similarity to cell membranes of the human body makes them nontoxic, biocompatible and biodegradable. This small size of liposomes guarantee high bioavailability of the drug for the organism.
  LIPOSHELL® products are manufactured in the highest quality standards, based on innovative technological processes giving them unique features on a global scale. Well designed and optimized liposomal formulation was based on the results from the molecular dynamics studies, for precise location of the Vitamin D in the lipid bilayer.

THE MAIN CAUSES OF VITAMIN-D DEFICIENCY:

Insufficient Skin Synthesis: Lifestyle / Use of Cosmetics with UV filters / Dark skin complexion / Skin ageing (age >65) / Latitude of residence / Skin transplant.
Reduced Absorption: Cystic fibrosis / Coeliac disease / Whipple’s disease / Crohn’s disease / Bariatric surgery / Drugs reducing cholesterol absorption.
Obesity: Sequestration in the adipose tissue. In individuals with obesity, there is an increased amount of adipose tissue due to an excess accumulation of body fat. While vitamin D is stored in fat cells, it may not be as readily available for use by the body.
Use of Certain immunosuppressive drugs: Reduced synthesis, Increased breakdown leading to lower levels, hindering vitamin D absorption.
Liver Dysfunction/liver disease or hepatic impairment: Disrupt bile flow, hinders vitamin D synthesis and metabolism. Reduced synthesis of 25(OH)D
Nephrotic syndrome: Increased loss of 25(OH)D in urine. Reduced production of  vitamin D, Increased protein loss, malabsorption of nutrients due to some medications.
Kidney disorders: Reduced synthesis of 1.25(OH)2D
Hereditary disorders: Genetic mutations causing rickets or resistance to vitamin D
Acquired disorders: Primary hypoparathyroidism / Hyperthyroidism / Granulomatous diseases (e.g. sarcoidosis, tuberculosis) / Some lymphomas
Insufficient supplementation: Too low supplementation dose / Irregular supplementation.

INGREDIENTS, USAGE AND NUTRITIONAL INFORMATION

Cholecalciferol (Vitamin D); Acidity regulator: Ascorbic acid; Water; Bulking agent: Glycerol; Stabiliser: Pectins; Natural flavouring; Phospholipids from Soy Lecithin. Contains naturally occurring sugars.
One sachet of VITA-D-LIP 4000 IU contains 100 µg (microgram)/1000% of Nutrient Vitamin D (cholecalciferol).

Daily Dose – Adults: 1 sachet once daily. The content of the sachet can be consumed directly, or dissolved in a small amount (1-3 oz or 25-75 ml) of still water .

Packaging: VITA-D-LIP 4000 IU 30 sachets of 5 g each

Flavor: VITA-D-LIP 4000 IU has the form of Liposomal gel with Melon flavor.
VITA-D-LIP 4000 IU is intended for adults with an increased demand for vitamin D.
VITA-D-LIP 4000 IU can be directly ingested, or dissolved in a small amount of still water.

General Precaution:

Do not exceed the recommended daily intake.
Do not dissolve the content of the sachet in hot beverages.
It is advisable to perform a 25(OH)D blood test and consult the doctor or pharmacist before use.
Do not use a food supplement as a substitute for a varied diet. A balanced diet and healthy lifestyle are recommended.
Pregnant or breastfeeding: If you are pregnant or breastfeeding, consult your healthcare professional before taking VITA-D-LIP.
Kidney disorders: People suffering from kidney disorders, kidney stones or hemochromatosis should consult a medical professional before using any product containing VITA-D-LIP.

Source: VITA-D-LIP 4000 IU is based on ingredients NOT Genetically Modified. They contain NO Added Sugars NO Gluten. Suitable for VEGANS.

General Information

In addition to the possibility of obtaining Vitamin D2 (ergocalciferol) and Vitamin D3 (cholecalciferol) from food sources, the human body has the ability to independently produce vitamin D3 through skin synthesis. This transformation pathway satisfies 80–100% of the daily requirement; however, it is dependent on many factors (read more – causes of vitamin D deficiency).

Vitamins D2 and D3 supplied with food are also subject to further metabolism in the liver and kidneys.

Skin synthesis of vitamin D3 (cholecalciferol)
Sun radiation penetrates into the deeper layers of the epidermis (the basal and spinous layers). These layers contain a cholesterol derivative called 7-dehydrocholesterol (provitamin D3), which under the influence of UVB radiation with a length of 290–315 nm is transformed by photoisomerization into pre-vitamin D3, which in turn is transformed into vitamin D3 (cholecalciferol) in a temperature-dependent reaction.
Vitamin D3 can be both stored in fat cells and released into the intercellular spaces, and then into the blood, where it is transported using the DBP protein carrier (Vitamin D-binding protein) to the liver, where it undergoes further transformation.
Renal (Kidney) synthesis
25(OH)D is transmitted, also in combination with the binding protein (DBP), from the liver to the kidneys (as well as to certain other tissues, e.g. the skin, large intestine and immune cells), where, by the action of the enzyme 1α-hydroxylase, a fully active form of vitamin D, 1.25(OH)2D, is formed.
Hepatic (Liver) synthesis 
Vitamin D2 and D3 produced in the skin or supplied with food, in combination with the DBP binding protein, is transported to the liver, where the first stage of biosynthesis of the active form of vitamin D takes place. After enzymatic hydroxylation,
25-hydroxy vitamin D – 25(OH)D is formed at the C 25 carbon

VITA-D-LIP – THE HIGH QUALITY PRODUCT